Elisabeth I Heath Selected Research

ASG-5ME

10/2019

A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer.

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Elisabeth I Heath Research Topics

Disease

49	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 09/2005
46	Neoplasms (Cancer) 01/2022 - 04/2007
10	Carcinoma (Carcinomatosis) 01/2022 - 02/2002
7	Fatigue 01/2022 - 03/2012
5	Adenocarcinoma 01/2022 - 02/2002
5	Circulating Neoplastic Cells 01/2022 - 01/2013
5	Neoplasm Metastasis (Metastasis) 12/2021 - 10/2016
5	Disease Progression 11/2020 - 01/2013
4	Carcinogenesis 01/2022 - 08/2006
3	Pain (Aches) 01/2022 - 12/2010
3	Hypoxia (Hypoxemia) 12/2019 - 03/2008
3	Exanthema (Rash) 10/2019 - 04/2007
3	Renal Cell Carcinoma (Grawitz Tumor) 08/2019 - 01/2014
3	Barrett Esophagus (Barrett's Esophagus) 01/2009 - 04/2007
3	Esophageal Neoplasms (Esophageal Cancer) 04/2007 - 02/2002
2	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2018
2	Abdominal Pain (Pain, Abdominal) 01/2022 - 10/2019
2	Neutropenia 10/2019 - 10/2019
2	Diarrhea 10/2019 - 04/2007
2	Nausea 04/2016 - 03/2016
2	Hypertension (High Blood Pressure) 03/2016 - 01/2016
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2012 - 04/2007
1	Urologic Neoplasms (Urological Cancer) 01/2022
1	Hypertriglyceridemia 01/2022
1	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/2022
1	Anemia 01/2022
1	Vomiting 01/2022
1	Rare Diseases (Rare Disease) 01/2022
1	Cranial Nerve Diseases (Cranial Nerve Disorders) 10/2021
1	Pruritus (Itching) 07/2021
1	Arthralgia (Joint Pain) 07/2021

Drug/Important Bio-Agent (IBA)

10	Pharmaceutical PreparationsIBA 01/2022 - 08/2006
10	AndrogensIBA 01/2022 - 01/2013
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2009
7	Proteins (Proteins, Gene)FDA Link 06/2021 - 03/2008
6	Prostate-Specific Antigen (Semenogelase)IBA 01/2022 - 07/2007
6	enzalutamideIBA 01/2022 - 10/2018
6	Hormones (Hormone)IBA 01/2021 - 09/2005
6	Celecoxib (Celebrex)FDA Link 10/2009 - 12/2002
5	PlatinumIBA 01/2022 - 04/2007
5	enfortumab vedotinIBA 01/2022 - 10/2019
4	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 01/2012
4	Tyrosine Kinase InhibitorsIBA 01/2021 - 04/2007
4	Immunoconjugates (Immunoconjugate)IBA 01/2021 - 01/2018
4	Docetaxel (Taxotere)FDA Link 12/2019 - 02/2002
3	Abiraterone AcetateIBA 01/2022 - 01/2021
3	Immune Checkpoint InhibitorsIBA 01/2022 - 01/2021
3	Carboplatin (JM8)FDA LinkGeneric 10/2019 - 09/2011
3	Biological ProductsIBA 04/2016 - 08/2006
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2022 - 12/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2018
2	Drug CombinationsIBA 01/2022 - 04/2007
2	Histone Deacetylase InhibitorsIBA 01/2022 - 12/2018
2	Prednisone (Sone)FDA LinkGeneric 12/2021 - 01/2021
2	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 01/2021
2	bicalutamide (Casodex)FDA LinkGeneric 01/2021 - 05/2015
2	taxaneIBA 01/2020 - 10/2019
2	B7-H1 AntigenIBA 10/2019 - 01/2018
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2018 - 12/2008
2	LigandsIBA 10/2018 - 11/2012
2	Cytotoxins (Cytolysins)IBA 01/2018 - 01/2009
2	Growth Factor ReceptorsIBA 11/2016 - 08/2006
2	Gefitinib (Iressa)FDA Link 11/2016 - 04/2007
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2016 - 03/2008
2	pazopanib FDA Link 03/2013 - 08/2012
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2012 - 08/2006
2	Paclitaxel (Taxol)FDA LinkGeneric 12/2011 - 09/2011
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 10/2009 - 04/2007
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	TransferasesIBA 01/2022
1	Bone Morphogenetic Protein 7IBA 01/2022
1	vistusertibIBA 01/2022
1	Estrogen ReceptorsIBA 01/2022
1	Histones (Histone)IBA 01/2022
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2022
1	YM753 compoundIBA 01/2022
1	Mifepristone (RU 486)FDA Link 01/2022
1	p38 Mitogen-Activated Protein KinasesIBA 01/2022
1	Oxidoreductases (Dehydrogenase)IBA 01/2022
1	Ethanol (Ethyl Alcohol)IBA 01/2022
1	Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))IBA 01/2022
1	IsoenzymesIBA 01/2022
1	AZD8186IBA 01/2022
1	DepsipeptidesIBA 01/2022
1	acetyl- 2- naphthylalanyl- 3- chlorophenylalanyl- 1- oxohexadecyl- seryl- 4- aminophenylalanyl(hydroorotyl)- 4- aminophenylalanyl(carbamoyl)- leucyl- ILys- prolyl- alaninamide FDA Link 12/2021
1	antiarrhythmic peptide (AAP)IBA 12/2021
1	Testosterone (Sustanon)FDA Link 12/2021
1	pexidartinibIBA 07/2021
1	Macrophage Colony-Stimulating FactorIBA 07/2021
1	Amylases FDA Link 07/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 06/2021

Therapy/Procedure

29	Therapeutics 01/2022 - 03/2008
18	Castration 01/2022 - 01/2013
10	Drug Therapy (Chemotherapy) 01/2022 - 02/2002
5	Radiotherapy 12/2021 - 02/2002
4	Chemoprevention 04/2016 - 04/2007
3	Prostatectomy (Retropubic Prostatectomy) 12/2021 - 10/2009
2	Immunotherapy 01/2021 - 08/2006
2	Precision Medicine 12/2018 - 05/2015
1	Intravenous Infusions 01/2022